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KMID : 1161420130160090839
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Journal of Medicinal Food
2013 Volume.16 No. 9 p.839 ~ p.846
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Renoprotective Effect of Coccinia indica Fruits and Leaves in Experimentally Induced Diabetic Rats
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Gurukar Mallur Somasundra Abignan
Mahadevamma Siddaiah
Chilkunda Nandini Dattatreya
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Abstract
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Diabetic nephropathy is one of the secondary complications of diabetes mellitus that is marked by changes in extracellular matrix components leading to end-stage renal failure. Diet plays an important role in managing diabetes. In the present study, the effect of Coccinia indica consumption on diabetes-mediated kidney damage was determined. Both control and diabetic rats were fed with AIN-76 diet supplemented with C. indica fruits and leaves individually at 10% and 5%, respectively, for a period of 2 months. Various parameters, such as fasting blood glucose, urine sugar, albumin excretion, kidney index, and glomerular filtration rate, were ameliorated to various extents by the supplementation of C. indica in the diet. Additionally, diabetic rats fed with diet supplemented with C. indica fruits or leaves showed improvement in glucose tolerance compared to control diabetic rats. They also exhibited beneficial effects on key antioxidant enzymes of the kidney. Furthermore, an increase in laminin and fibronectin as a result of diabetes was alleviated in C. indica-fed rats. These results indicate that the consumption of C. indica is beneficial in partially containing diabetes-mediated deleterious effects on the kidney.
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KEYWORD
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albumin excretion, Coccinia indica, diabetes mellitus, extracellular matrix components, kidney index
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